Over the last decade, advances in next-generation sequencing technology have given rise to many findings increasing our understanding of human disease and natural variation within species. Sequencing of the exome, the small fraction of the genome encompassing all exons of protein coding genes, has gained popularity as an inexpensive alternative to sequencing the entire genome. In a recent issue of G3, Warr et al. review details of the method of exome sequencing, its uses in humans and other species, and its potential benefits. Check out my article about it on Genes to Genomes!